Strategic and scientific contributions of human challenge trials for Strep A vaccine development: facts versus fantasy (#162)

5:30 PM

Yara-Natalie Abo

Poster Session 1

From random towards randomised care of patients with invasive streptococcal infections – current clinical practice and areas of equipoise (117612)

10:03 AM

Katherine B Gibney

Plenary 10 - Invasive Disease

Cracking the nut of clinical trials to test interventions for life threatening gram-positive toxin-mediated syndromes (#140)

5:30 PM

Hadar Mudrik-Zohar

Poster Session 1

CHIVAS-M1: No strain, no gain. Choosing an M1_UK human challenge strain. (#164)

5:30 PM

Kristy I Azzopardi

Poster Session 1

Killing Strep A softly – towards standardised reagents for Streptococcus pyogenes immunoassays (#202)

5:30 PM

Kristy I Azzopardi

Poster Session 2

Salivary signatures: mapping the dynamic human proteome in Strep A pharyngitis (118109)

11:44 AM

Anuk D Indraratna

Plenary 6 - Lessons From Niches of Stress, Vulnerability, and Resilience

Phase I Trial of a Peptide-based Vaccine to Prevent Group A Streptococcal Infection (118111)

9:15 AM

Michael F. Good

Plenary 5 - Interventions for Prevention

Putting public enemy #M1_UK in the human challenge crosshairs (#168)

5:30 PM

Kimberly Davis

Poster Session 1

Towards a Human Whole Blood in Tube Assay to Measure Cellular Immunity to Streptococcus pyogenes Vaccine Antigens (#167)

5:30 PM

Natalie Caltabiano

Poster Session 1

Population pharmacokinetics of penicillin G: insights into increased clearance at low concentrations to guide development of improved long-acting formulations for syphilis and prevention of rheumatic fever (#135)

5:30 PM

Laurens Manning

Poster Session 1

The experience of streptococcal pharyngitis human challenge trial participants (#284)

5:30 PM

Jane Oliver

Poster Session 2

M1 and done? Converging on a globally representative set of more and less invasive group a streptococcal strains (#113)

5:30 PM

Gabrielle de Crombrugghe

Poster Session 1

Experimental human infection with Streptococcus pyogenes alters the magnitude and phenotype of vaccine antigen-specific memory B cells (116679)

4:55 PM

Holly A Fryer

Plenary 4 - Rapid Fire Session

Junk or adjunct? The place of protein synthesis inhibitors for treatment of severe invasive Streptococcus pyogenes infections in a time of rising clindamycin resistance (#218)

5:30 PM

Louise Kelly

Poster Session 2

A randomised, double-blinded, placebo-controlled human challenge trial to establish the lowest penicillin concentration to prevent Streptococcus pyogenes pharyngitis (CHIPS). (118511)

9:39 AM

Laurens Manning

Plenary 5 - Interventions for Prevention

Sugar-Coated or Protein-Packed? How antigen type shapes the B cell response against Streptococcus pyogenes in humans (118522)

4:15 PM

Danika L Hill

Concurrent 2a - Immunity, The Good, Bad, and Ugly

Colonization with Streptococcus pyogenes elicits robust B cell responses against conserved vaccine antigens in paediatric tonsils (#191)

5:30 PM

Catherine Pitt

Poster Session 1

The dynamic human systemic transcriptomic signature of Streptococcus pyogenes pharyngitis (119137)

11:15 AM

Hannah R Frost

Plenary 11 - Lancefield Time Machine - The Shape of Things to Come